by Dr. Leo Galland
The dietary supplement lactoferrin is the subject of promising research for its ability to augment drug therapy for candida (yeast).
Scientists at the University Centre for Pharmacy in The Netherlands looked at potential beneficial drug-supplement interaction between lactoferrin and fluconazole (brand name Diflucan), a drug used for treating yeast infections.
According to the scientists, failures in the treatment of difficult cases of candida call for new treatments to support the activity of the common antifungal agents. They studied the effect of lactoferrin used with three different antifungal drugs and found that: “The use of lactoferrin and fluconazole appeared to be the most successful combination. Significant reductions in the minimal effective concentrations of fluconazole were found when it was combined with a relatively low lactoferrin concentration.” (Kuipers ME, et al.)
Please see abstract below for more information.
Reference and Abstract:
Antimicrob Agents Chemother. 1999 Nov;43(11):2635-41. Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates. Kuipers ME, de Vries HG, Eikelboom MC, Meijer DK, Swart PJ.Section of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Studies, University Centre for Pharmacy, 9713 AV Groningen, The Netherlands. email@example.com
Because of the rising incidence of failures in the treatment of oropharyngeal candidosis in the case of severely immunosuppressed patients (mostly human immunodeficiency virus [HIV]-infected patients), there is need for the development of new, more effective agents and/or compounds that support the activity of the common antifungal agents. Since lactoferrin is one of the nonspecific host defense factors present in saliva that exhibit antifungal activity, we studied the antifungal effects of human, bovine, and iron-depleted lactoferrin in combination with fluconazole, amphotericin B, and 5-fluorocytosine in vitro against clinical isolates of Candida species. Distinct antifungal activities of lactoferrin were observed against clinical isolates of Candida. The MICs generally were determined to be in the range of 0.5 to 100 mg. ml(-1). Interestingly, in the combination experiments we observed pronounced cooperative activity against the growth of Candida by using lactoferrin and the three antifungals tested. Only in a limited concentration range was minor antagonism detected. The use of lactoferrin and fluconazole appeared to be the most successful combination. Significant reductions in the minimal effective concentrations of fluconazole were found when it was combined with a relatively low lactoferrin concentration (1 mg/ml). Such combinations still resulted in complete growth inhibition, while synergy of up to 50% against several Candida species was observed. It is concluded that the combined use of lactoferrin and antifungals against severe infections with Candida is an attractive therapeutic option. Since fluconazole-resistant Candida species have frequently been reported, especially in HIV-infected patients, the addition of lactoferrin to the existing fluconazole therapy could postpone the occurrence of species resistance against fluconazole. Clinical studies to further elucidate the potential utility of this combination therapy have been initiated