Grape Ingredient Resveratrol Increases Beneficial Fat Hormone

Grape Ingredient Resveratrol Increases Beneficial Fat Hormone

University of Texas researchers find that resveratrol increases adiponectin levels.


Resveratrol, a compound in grapes, displays antioxidant and other positive properties. In a study published this month, researchers at the UT Health Science Center San Antonio describe a novel way in which resveratrol exerts these beneficial health effects.


Resveratrol stimulates the expression of adiponectin, a hormone derived from cells that manufacture and store fat, the team found. Adiponectin has a wide range of beneficial effects on obesity-related medical complications, said senior author Feng Liu, Ph.D., professor of pharmacology and member of the Barshop Institute of Longevity and Aging Studies at the Health Science Center.


Both adiponectin and resveratrol display anti-obesity, anti-insulin resistance and anti-aging properties.


“Results from these studies should be of interest to those who are obese, diabetic and growing older,” Dr. Liu said. “The findings should also provide important information on the development of novel therapeutic drugs for the treatment of these diseases.”


The researchers confirmed the finding in cells and animal models. The study is in the Jan. 7 issue of the Journal of Biological Chemistry.


Previous studies


In July 2009 in the journal Nature, the Barshop Institute and collaborators reported that the compound rapamycin extended life in mice. Rapamycin, like resveratrol, is under scrutiny for its beneficial health effects.


In 2010, Dr. Liu and colleagues announced that resveratrol inhibits activity of the mammalian target of rapamycin (mTOR). This discovery was included in the prestigious Faculty of 1000 (F1000), a service that identifies and evaluates the most important articles in biology and medical research publications. The selection process involves a peer-nominated global “faculty” of the world’s leading scientists and clinicians who rate the best of the articles they read and explain their importance.


A reviewer said the study, which appeared in the Journal of Biological Chemistry, would open up work in a new area: explaining how resveratrol and rapamycin synergistically achieve their results.




The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 3 percent of all institutions worldwide receiving National Institutes of Health (NIH) funding. Research and other sponsored program activity totaled a record $259 million in fiscal year 2009. The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced approximately 26,000 graduates. The $744 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information, visit



2 thoughts on “Grape Ingredient Resveratrol Increases Beneficial Fat Hormone

  1. Pingback: Leo Galland, M.D.: Slimming Strawberries For Weight Loss

  2. Pedro

    Regarding Vit D and obesity. My peorsnal experience on 5000 IU/day even with co-factors for over 3 years, still led to a Vit D level of 17 ng/ml, much to my surprise. The problem was due to malabsorption and with supplementation of a probiotic blend, the Vit D levels were corrected within a year to 54 ng/ml and have been stable ever since. Interestingly, having already lost 70 pounds and now of normal weight, I was still carrying around a bit of excess body fat. Over the course of the same year, I lost 10% body fat and 5 more pounds. Metabolically, this would make sense, with improved absorption of both calcium & Vit D and the improved hormone signaling of Insulin, Cortisol & Leptin. Aside from myself, I am seeing them same help with fat loss, with my clients on 4000-5000 IU supplementation a day with a probiotic blend, high fiber diet and better Insulin control.

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